神经生物学,Taghert博士应邀来研究所进行学术交流

二〇〇八年3月15日,Washington高校约旦安曼分校艺术大学解剖学和神经生物学系教师PaulH.
Taghert博士应邀来研商所开始展览学术沟通。Taghert大学生的讲座标题为:Neuronal
mechanisms underlying circadian control of behavior in
Drosophila。饶毅博士主持讲座。

澳门24小时用心打造,www.5524.com,二零一六年九月16日,美利坚联邦合众国威斯康星州高校理大学(University of Massachusetts
Medical School)神经生物学(Department of Neurobiology)教师PatrickEME奥迪Q5Y 大学生应邀做客切磋所并进行学术讲座。讲座的主题素材为:Synchronization of
circadian rhythms in Drosophila。张二荃大学生主持讲座。

澳门24小时娱乐,2012年一月二十八日,U.S.A.内布Russ加农工博士物系讲明Paul EricHardin学士应邀做客斟酌所并设置学术讲座。讲座的难点为:Molecular genetic
analysis of the circadian timekeeping mechanism in
Drosophila。张二荃大学生主持讲座。

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Abstract:

Abstract:

Abstract:

Drosophila exhibit daily rhythms of locomotion under the influence of
environmental signals and of an internal circadian clock. The clock
operates in approximately 150 identified pacemaker neurons which are
diverse, and spatially distributed in the brain. We are interested in
the neuronal circuits in which these pacemakers participate. We study
their properties as individual nerve cells, their mechanisms of
circadian synchronization and their contributions to the generation of
rhythmic behavior.

Circadian clocks integrate light and temperature input to remain
synchronized with the day/night cycle. In Drosophila, circadian
photoreception is based on cell-autonomous detection of light by the
photoreceptor CRYPTOCHROME . CRY targets the key circadian pacemaker
protein TIMELESS for proteasomal degradation. The molecular mechanisms
by which circadian clocks respond to temperature remain however poorly
understood. We found that temperature phase-shifts Drosophila circadian
clocks through degradation of the pacemaker protein TIMELESS . This
degradation is mechanistically distinct from photic CRY-dependent TIM
degradation. Thermal TIM degradation is triggered by cytosolic calcium
increase and CALMODULIN binding to TIM, and is mediated by the atypical
calpain protease Small Optic Lobes . This thermal input pathway and
CRY-dependent light input thus converge on TIM, providing a molecular
mechanism for the natural integration of circadian light and temperature
inputs.

The identification and analysis of clock genes in the fruit fly,
Drosophila melanogaster, revealed that the circadian clock is based on
interlocked feedback loops in gene expression. Similar feedback loops
serve to keep circadian time in essentially all eukaryotes, and the
genes that mediate feedback loop function are well conserved from
insects to mammals. A key function of these feedback loops is that they
drive circadian rhythms in transcription that are required to keep
circadian time and drive overt rhythms in physiology, metabolism and
behavior. However, the extent to which different feedback loops
contribute to clock function and how they maintain a 24h period is not
well understood. Here I will describe recent experiments that shed light
on post-translational regulatory mechanisms and importance of
interlocked loops for keeping circadian time and driving overt rhythms.

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